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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Cross-reactivity00:42

Cross-reactivity

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Related Experiment Video

Updated: Jul 3, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Food allergy.

Thomas Werfel1

  • 1Department of Dermatology and Venerology, Medical University of Hannover, Germany. werfel.thomas@mh-hannover.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|July 10, 2008
PubMed
Summary
This summary is machine-generated.

Food allergy involves sensitization to food allergens, often causing immediate skin reactions. Diagnosis requires a careful approach, with oral food challenges confirming allergies and elimination diets being the only proven treatment.

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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Area of Science:

  • Immunology
  • Allergology
  • Clinical Medicine

Background:

  • Food allergy is an immune response to food allergens, frequently causing immediate reactions, primarily affecting the skin.
  • Reactions can be immunoglobulin E (IgE)-mediated or T-lymphocyte-mediated, as seen in atopic dermatitis.
  • In adults, cross-reactivity between foods and inhaled allergens accounts for a significant portion of food allergies.

Purpose of the Study:

  • To outline the diagnostic and therapeutic landscape of food allergies.
  • To emphasize the importance of individualized diagnostic procedures.
  • To review current and emerging treatment strategies for food allergies.

Main Methods:

  • Review of diagnostic approaches for food allergy.
  • Emphasis on the role of oral provocation tests for diagnosis.
  • Discussion of elimination diets as a primary intervention.

Main Results:

  • The diagnostic algorithm for food allergy is similar to other allergic conditions.
  • Oral provocation is the gold standard for confirming food allergy when history is unclear.
  • Specific elimination diets are the only established effective intervention.

Conclusions:

  • Accurate diagnosis of food allergy relies on a stepwise, individualized approach.
  • Oral food challenges and elimination diets are crucial components of management.
  • Emerging therapies like immunotherapy and anti-IgE treatments require further investigation.