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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Published on: July 24, 2021

Cefuroxime axetil.

P Dellamonica1

  • 1Department of Infectious Diseases, Archet Hospital, BP 79, 06202 Nice Cedex 3, France.

International Journal of Antimicrobial Agents
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Cefuroxime axetil, a second-generation cephalosporin antibiotic, effectively treats various bacterial infections, including respiratory and genito-urinary tract infections. Pharmacokinetic studies confirm its good bioavailability and tissue penetration for therapeutic use.

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Assay Development for High-Throughput Drug Screening Against Mycobacteria
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Published on: October 25, 2024

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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Assay Development for High-Throughput Drug Screening Against Mycobacteria
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Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Antibiotic Therapy

Background:

  • Cefuroxime is a widely used, semi-synthetic, second-generation cephalosporin antibiotic.
  • Cefuroxime axetil is an orally administered ester prodrug of cefuroxime.
  • It exhibits broad-spectrum activity against common respiratory and other pathogens.

Purpose of the Study:

  • To review the efficacy and pharmacokinetic properties of cefuroxime axetil.
  • To outline its indications and dosing regimens for various bacterial infections.

Main Methods:

  • Review of pharmacokinetic studies assessing absorption, bioavailability, and tissue distribution.
  • Summary of clinical data on efficacy against susceptible microorganisms.
  • Analysis of adverse reaction profiles.

Main Results:

  • High sensitivity of common respiratory pathogens (e.g., Haemophilus influenzae, Streptococcus pneumoniae) and other bacteria (e.g., E. coli, S. aureus) to cefuroxime.
  • Good oral bioavailability (68%) and plasma concentrations achieved with cefuroxime axetil.
  • Effective treatment of lower and upper respiratory tract infections, genito-urinary tract infections, and skin/soft tissue infections.

Conclusions:

  • Cefuroxime axetil is a valuable therapeutic option for infections caused by susceptible bacteria.
  • Appropriate dosing regimens ensure effective treatment with generally mild and transient adverse effects.