Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

304
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
304
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

242
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
242
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

936
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
936
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

45.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.9K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

118
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
118
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

163
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
163

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

[Rational use of antibiotics treatment in acute bronchitis].

Medecine et maladies infectieuses·2024
Same author

E-health. Patterns of use and perceived benefits and barriers among people living with HIV (PLHIV) and their physicians - Part 3: Telemedicine and collection of computerized personal information.

Medecine et maladies infectieuses·2020
Same author

E-health. Patterns of use and perceived benefits and barriers among people living with HIV and their physicians. Part 2: Health apps and smart devices.

Medecine et maladies infectieuses·2020
Same author

E-health. Patterns of use and perceived benefits and barriers among people living with HIV and their physicians. Part 1: Information retrieval on the Internet and social networks.

Medecine et maladies infectieuses·2020
Same author

A decreasing CD4/CD8 ratio over time and lower CSF-penetrating antiretroviral regimens are associated with a higher risk of neurocognitive deterioration, independently of viral replication.

Journal of neurovirology·2016
Same author

Characteristics and consequences of medical care interruptions in HIV-infected patients in France.

Epidemiology and infection·2016
Same journal

[Etiology and clinical expression of angina].

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
Same journal

[Detection of human rotaviruses in faeces : comparison of five methods].

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

12.3K

[Diarrhea and HIV infection].

P Dellamonica1

  • 1Service des maladies infectieuses et tropicales, hôpital de l'Archet, route Saint-Antoine Ginestière, 06200 Nice, France.

Medecine Et Maladies Infectieuses
|April 15, 2024
PubMed
Summary
This summary is machine-generated.

Highly Active Antiretroviral Therapies (HAART) improve HIV replication but can cause diarrhea. Simple therapies, including diet, can manage this side effect, improving patient quality of life.

Keywords:
DiarrhoeaHIV InfectionsProtease inhibitors

More Related Videos

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

15.7K
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.4K

Related Experiment Videos

Last Updated: Jun 28, 2025

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

12.3K
Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

15.7K
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.4K

Area of Science:

  • Antiviral Therapy Research
  • Gastroenterology
  • Infectious Disease Management

Context:

  • Highly Active Antiretroviral Therapies (HAART), especially protease inhibitors, have significantly improved HIV replication control.
  • Diarrhea remains a common side effect, impacting patient quality of life despite treatment efficacy.
  • Infectious causes of diarrhea must be ruled out in general practice.

Purpose:

  • To review the incidence, severity, and impact of diarrhea associated with protease inhibitor therapy in HIV patients.
  • To assess the effect of diarrhea on antiretroviral treatment adherence and efficacy.
  • To recommend management strategies for improving patient quality of life.

Summary:

  • Protease inhibitor-associated diarrhea is typically low-grade, often occurring early in treatment, and rarely leads to discontinuation (<2%).
  • Diarrhea does not significantly compromise the medium-term efficacy of protease inhibitors in controlling HIV replication.
  • Despite minimal impact on efficacy, diarrhea negatively affects patients' quality of life, necessitating management interventions.

Impact:

  • Highlights the need for proactive management of diarrhea to enhance patient adherence and well-being.
  • Suggests simple therapeutic approaches, including dietary modifications, to mitigate diarrhea incidence and consequences.
  • Emphasizes the importance of addressing side effects to optimize long-term HIV management and improve patient outcomes.