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Related Experiment Video

Updated: Jun 28, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
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[Necrotizing enterocolitis in a premature infant].

R Mettey1, G Agius2, C Cessans1

  • 1Clinique Médicale des Enfants, CHU La Milétrie, BP 577, F-86021 Poitiers cedex, France.

Medecine Et Maladies Infectieuses
|April 15, 2024
PubMed
Summary
This summary is machine-generated.

Necrotizing enterocolitis in a premature infant was linked to Adenoviruses, not typical causes. This case highlights the need for thorough pathogen investigation in neonatal gut diseases.

Keywords:
AdenovirusesNecrotizing enterocolitisPremature infant

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Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Infectious Diseases

Context:

  • Necrotizing enterocolitis (NEC) is a serious gastrointestinal emergency in premature infants.
  • The etiology of NEC is multifactorial, often involving prematurity, feeding, and gut microbiome alterations.
  • Ischemic and common bacterial/parasitic causes were ruled out in this case.

Purpose:

  • To report an unusual case of NEC in a premature infant.
  • To investigate the potential role of viral pathogens in NEC.
  • To emphasize the importance of comprehensive microbiological diagnostics in NEC.

Summary:

  • A 30-week premature infant developed necrotizing enterocolitis (NEC) despite being fed breast milk and having no ischemic factors.
  • Standard bacteriological and parasitological tests were negative.
  • A positive latex agglutination test for Adenoviruses in stool samples coincided with bloody diarrhea.

Impact:

  • This case suggests a potential, previously under-recognized role for Adenoviruses in the pathogenesis of NEC.
  • Highlights the need for expanded etiological investigations in NEC, including viral screening.
  • Underscores the importance of understanding the diverse roles of pathogens in neonatal diseases.