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Updated: Jul 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Cefpodoxime proxetil: a comprehensive review

W M Todd1

  • 1Upjohn Laboratories, The Upjohn Company, 7000 Portage Road, Kalamazoo, MI 49001, USA.

International Journal of Antimicrobial Agents
|March 1, 1994
PubMed

Insights

Cefpodoxime proxetil is a well-tolerated oral antibiotic effective against many common bacterial infections, including respiratory and urinary tract infections. It shows broad-spectrum activity, particularly against Gram-negative and some Gram-positive bacteria.

Area of Science:

  • Pharmacology and Microbiology
  • Infectious Diseases

Background:

  • Cefpodoxime proxetil is a third-generation cephalosporin antibiotic.
  • It offers broad-spectrum in vitro activity against various bacterial pathogens.

Purpose of the Study:

  • To evaluate the in vitro activity and clinical utility of cefpodoxime proxetil.
  • To highlight its effectiveness in treating common infections.

Main Methods:

  • In vitro susceptibility testing against key bacterial species.
  • Review of clinical applications in treating infections.

Main Results:

  • Demonstrated excellent in vitro activity against Enterobacteriaceae, Hemophilus spp., and Moraxella spp., including beta-lactamase producers.
  • Showed good activity against streptococci but no activity against enterococci.
  • Well-tolerated oral formulation with demonstrated utility in respiratory, urinary, skin, and other infections.

Conclusions:

  • Cefpodoxime proxetil is a valuable oral therapeutic option for various bacterial infections.
  • Its broad spectrum and good tolerability make it suitable for common clinical use.

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