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Updated: Jul 3, 2026
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Use of antimicrobial drugs in developing countries
1Department of Internal Medicine, The Ohio State University, M110 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA.
International Journal of Antimicrobial Agents
|April 1, 1995
Summary
The rise of antibiotic resistance threatens modern medicine. Slowing its spread requires reducing infectious diseases and curbing inappropriate antibiotic use globally.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Antimicrobial therapy has saved millions of lives over seven decades.
- The global emergence of resistant microbial strains poses a significant threat to these advancements.
Purpose of the Study:
- To highlight the escalating crisis of antimicrobial resistance.
- To discuss the factors driving resistance and propose mitigation strategies.
Main Methods:
- Review of scientific literature on antimicrobial resistance.
- Analysis of factors contributing to resistance, including microbial genetics, antibiotic use, and socioeconomic influences.
Main Results:
- Genetic diversity and transfer of resistance among microbes accelerate the problem.
- Inappropriate antibiotic promotion and use are key selective forces.
Conclusions:
- New drug development alone is unlikely to solve the resistance crisis.
- Reducing the global burden of infectious diseases through improved sanitation, nutrition, and immunization is crucial.
- Enhanced education on antibiotic use and responsible pharmaceutical practices are essential to combat antimicrobial resistance.
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