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Biotin-rich intranuclear inclusions: have you checked your immunohistochemical controls?

Rania Bakkar1, Grace Moore, Alvin Martin

  • 1Department of Pathology and Laboratory Medicine, University of Louisville Hospital, Louisville, Kentucky, USA.

International Journal of Surgical Pathology
|July 10, 2008
PubMed

Abstract:

Intranuclear biotin interacts with avidin-biotin-complex used for viral immunoperoxidase detection giving false-positive results.

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