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Reaction of an Introverted Carboxylic Acid with Carbodiimide

Tetsuo Iwasawa1, Paul Wash, Christoph Gibson

  • 1The Skaggs Institute for Chemical Biology and Department of Chemistry The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037.

Tetrahedron
|July 10, 2008
PubMed

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Preparation of Amides

Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
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Carboxylic acids can be prepared by the carboxylation of Grignard reagents (RMgX). This method is convenient for converting alkyl (primary, secondary or tertiary), vinyl, benzyl, and aryl halides to carboxylic acids with one additional carbon than the starting RMgX.
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Acid-catalyzed hydrolysis:
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