Related Experiment Video
Updated: Jul 3, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
Published on: April 19, 2013
Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population
1Research Unit 'Targets for Diagnostic and Therapy of Human Diseases', Centre of Biotechnology of Sfax, and Laboratoire International Associé No 135, Sfax, Tunisia. kaouthar2005@gmail.com
Background:
T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case-control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM.
Research Design And Methods:
All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism.
Results:
Results showed that the GT genotype of XbaI SNP could increase the risk of susceptibility to T2DM to 2.4 and that TAT is a 'risk haplotype' conferring a risk of 3.4 to T2DM.
Conclusion:
The TAT haplotype of the GLUT1 gene confers susceptibility to T2DM in the Tunisian population.
Related Concept Videos
Type II Diabetes I: Introduction
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Diabetes Mellitus: Type 2 and Gestational
Type II Diabetes II: Pathophysiology
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters