Related Experiment Video
Updated: Jul 3, 2026
06:52
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Behavioural functioning of retinoblastoma survivors
J van Dijk1, K J Oostrom, S M Imhof
1Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands. jennifer.vandijk@vumc.nl
Psycho-Oncology
|July 10, 2008
Summary
Behavioral problems are common in retinoblastoma (RB) survivors, with parental reports indicating higher rates than self-reports. Hereditary RB, intensive treatment, and single-parent families increase behavioral risk in survivors.
Area of Science:
- Pediatric Oncology
- Child Psychology
- Ophthalmology
Background:
- Retinoblastoma (RB) survivors may experience long-term sequelae.
- Behavioral problems are a potential concern in childhood cancer survivors.
Purpose of the Study:
- To assess the prevalence and nature of behavioral problems in retinoblastoma survivors.
- To identify predictors of behavioral difficulties in this population.
Main Methods:
- Population-based cross-sectional study of 148 Dutch retinoblastoma survivors (aged 8-35).
- Utilized self-report and parental questionnaires to assess behavioral issues.
- Employed T-tests and multiple regression analyses for statistical evaluation.
Main Results:
- Parental reports indicated higher overall behavioral problems in younger survivors (8-17 years) compared to adolescent and adult self-reports.
- Significant differences noted in internalizing problems (boys) and somatic complaints (both genders) via parental reports.
- Self-reports revealed lower externalizing problems in women and fewer thought problems in female adolescents and adult men.
- Hereditary RB, intensive treatment, and single-parent families were associated with increased behavioral risk.
Conclusions:
- Perceptions of behavioral problems differ between reporters (parents vs. survivors) and across age groups.
- Health professionals must recognize the heightened risk of behavioral difficulties in survivors with hereditary RB, intensive treatment histories, or those from single-parent families.
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The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...