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Sexual Development in Perinatally HIV-Infected Young People: A Systematic Review and Explorative Study.
A M Ter Haar1, A Fieten1, M Van den Hof1
1Pediatric Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, The Netherlands.
Sexual Medicine
|October 24, 2022
Summary
Perinatally HIV-infected (PHIV) adolescents generally achieve sexual milestones similarly to their HIV-uninfected peers. While most studies show no difference in sexual activity rates, PHIV individuals may experience a slightly later debut.
Area of Science:
- Adolescent Health
- Infectious Diseases
- Sexual Health
Background:
- Adolescents with perinatally HIV infection (PHIV) may experience altered sexual development compared to their peers.
- Understanding sexual milestones in PHIV adolescents is crucial for comprehensive care and support.
Purpose of the Study:
- To systematically review and compare the sexual milestones of perinatally HIV-infected (PHIV) adolescents with HIV-uninfected controls.
- To investigate the occurrence and age of debut for various sexual milestones in PHIV versus HIV-uninfected individuals.
Main Methods:
- Conducted a systematic review across four databases (Medline, Embase, Web of Science, Scopus) following PRISMA guidelines.
- Included studies reporting quantitative data on sexual milestones in PHIV compared to HIV-uninfected control groups.
- Performed a qualitative synthesis of data and an explorative study with matched PHIV and HIV-uninfected controls.
Main Results:
- The systematic review included 18 studies involving 1,963 participants; most found no significant differences in intercourse occurrence or debut age.
- Few studies reported on other sexual milestones, with two of four showing no significant differences between PHIV and controls.
- The explorative study (10 PHIV, 16 controls) indicated a non-significant trend towards a later debut age for sexual milestones in PHIV.
Conclusions:
- Perinatally HIV-infected individuals generally achieve sexual milestones at rates similar to their HIV-uninfected peers.
- A tendency towards a later debut age for sexual milestones was observed in well-treated PHIV adolescents.
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