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Updated: Jul 3, 2026
10:29
Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
CD4+ T-regulatory cells: toward therapy for human diseases
Sarah E Allan1, Raewyn Broady, Silvia Gregori
1Department of Surgery, Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
Immunological Reviews
|July 11, 2008
Summary
Regulatory T-cells (Tregs) are crucial for immune tolerance. Manipulating these cells shows promise for treating conditions like autoimmunity and cancer, with human clinical trials anticipated soon.
Area of Science:
- Immunology
- Cellular Biology
- Therapeutic Development
Background:
- T-regulatory cells (Tregs) are vital for maintaining peripheral immune tolerance.
- Dysregulation of Treg numbers or function is linked to autoimmunity, allergies, and transplant rejection.
- Conversely, excessive Tregs can impair anti-tumor and anti-pathogen immune responses.
Purpose of the Study:
- To review the characteristics of human FOXP3(+) Tregs and Tr1 cells as therapeutic targets.
- To highlight progress and challenges in Treg-based therapeutic strategies for human application.
- To discuss methods for enhancing Tregs in vivo or ex vivo for adoptive transfer.
Main Methods:
- Review of current scientific literature on human Tregs.
- Analysis of experimental models demonstrating Treg manipulation efficacy.
- Discussion of in vitro and in vivo Treg modulation techniques.
Main Results:
- Tregs play a fundamental role in immune homeostasis.
- Mouse models show Treg manipulation can reduce pathology in various diseases.
- Human Treg-based therapies are most advanced for FOXP3(+) Tregs and Tr1 cells.
Conclusions:
- Treg-based therapies hold significant therapeutic potential for immune-related disorders.
- Overcoming technical and theoretical challenges is necessary for clinical translation.
- The next decade is expected to feature the first human clinical trials for Treg therapies.
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