[Radioimmunodiagnosis in the correction of plasmapheresis methodology in thyrotoxicosis]

Differences in the rated and actual results were revealed during postoperative plasmapheresis in patients with thyrotoxicosis who did not tolerate or were resistant to thyrostatics. It was assumed that it was caused by a rise of the level of thyroid hormones resulting from heparin premedication. Gravitation plasmapheresis following heparin administration (150-200 U per 1 kg of body mass) was used in a study group of 25 patients. A dynamic study of T4, T3 and TSH was conducted with the help of radioimmunodiagnosis, based on the antigen-antibody reaction using radioimmunoassay kits. The "euthyroid" effect of plasmapheresis was shown to change as a result of heparin premedication. A significant rise of the levels of T4 and T3 by 63 and 36% was proved. The mechanism of this change was considered. The results were used for a choice of an optimum combination plasma substitutes (a mixture of albumin--30% of the total volume of substitution, and rheopolyglycine) to enhance the efficacy of preoperative preparation.