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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jul 3, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

[New developments in cancer immunotherapy].

O Michielin¹, N Rufer, P Romero

¹Centre pluridisciplinaire d'oncologie, CHUV, Lausanne. Olivier.Michielin@unil.ch

Revue Medicale Suisse

|July 12, 2008

Summary

This summary is machine-generated.

Novel tumor immunotherapies, including peptide vaccines and adoptive T-cell transfer, show superior response rates compared to traditional treatments. Research in Lausanne focuses on melanoma, optimizing T-cell receptor (TCR) therapies.

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Area of Science:

Immunology
Oncology
Biotechnology

Context:

Advances in understanding the immune system's cellular and molecular mechanisms.
Emerging immunotherapies offer improved treatment outcomes for cancer.
Focus on melanoma treatment strategies.

Purpose:

To present current developments in tumor immunotherapy.
To highlight the Lausanne experience in melanoma treatment.
To discuss novel therapeutic approaches including vaccination and adoptive transfer.

Summary:

Presents advancements in peptide-based vaccination for cancer immunotherapy.
Details adoptive transfer strategies, emphasizing lymphodepletion for patient conditioning.
Describes a project focused on rational lymphocyte T-cell receptor (TCR) optimization.

Impact:

Novel immunotherapies demonstrate higher response rates than conventional treatments.
Optimized T-cell receptor therapies hold promise for enhanced melanoma treatment.
Lausanne's research contributes to the evolving field of cancer immunotherapy.