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Updated: Jul 3, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

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Published on: May 23, 2025

Periodontitis is associated with platelet activation.

Dimitris Papapanagiotou1, Elena A Nicu, Sergio Bizzarro

  • 1Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), Universiteit van Amsterdam and Vrije Universiteit, The Netherlands.

Atherosclerosis
|July 12, 2008
PubMed
Summary

Periodontitis, an oral inflammatory condition, is linked to increased platelet activation. This heightened platelet activity may contribute to the risk of cardiovascular disease (CVD) by promoting a pro-coagulant state.

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Area of Science:

  • Cardiovascular Research
  • Oral Health
  • Hematology

Background:

  • Periodontitis is epidemiologically associated with cardiovascular disease (CVD).
  • Periodontitis involves low-grade systemic inflammation and regular bacteremia, potentially leading to platelet activation and a pro-coagulant state.

Purpose of the Study:

  • To investigate platelet activation in patients with periodontitis.
  • To determine if periodontitis severity correlates with markers of platelet activation.

Main Methods:

  • Part 1: Measured plasma levels of soluble P-selectin and soluble CD40 ligand in 85 periodontitis patients and 35 controls.
  • Part 2: Assessed surface-bound P-selectin and glycoprotein IIb-IIIa activation (PAC-1 binding) on platelets from 18 periodontitis patients and 16 controls.

Main Results:

  • Periodontitis patients showed significantly elevated plasma levels of soluble P-selectin (P<0.001).
  • Increased PAC-1 binding to platelets was observed in periodontitis patients (P=0.033).
  • Platelet activation demonstrated a severity-dependent relationship with periodontal disease progression.

Conclusions:

  • Periodontitis is associated with significantly increased platelet activation.
  • Elevated platelet activation in periodontitis may contribute to atherothrombosis and explain the link between periodontitis and CVD.