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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Minocycline hepatitis.

Thomas J Ford1, John F Dillon

  • 1Department of Digestive Diseases and Clinical Nutrition, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK. thomasjford@gmail.com

European Journal of Gastroenterology & Hepatology
|July 12, 2008
PubMed
Summary
This summary is machine-generated.

Minocycline, an acne treatment, can cause autoimmune hepatitis. A young woman developed liver dysfunction after a year of minocycline, which resolved upon drug cessation, highlighting the need for monitoring.

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Published on: August 31, 2015

Area of Science:

  • Hepatology
  • Dermatology
  • Immunology

Background:

  • Minocycline is a widely prescribed antibiotic for acne vulgaris.
  • Long-term use of minocycline has been associated with various adverse effects.

Observation:

  • A 20-year-old woman presented with jaundice and malaise after one year of minocycline therapy for acne.
  • Laboratory tests revealed significantly elevated liver enzymes and a high titer of antinuclear antibodies (1:2560).
  • Other potential causes of liver disease were ruled out.

Findings:

  • The patient's symptoms and laboratory abnormalities resolved spontaneously after discontinuing minocycline.
  • The clinical presentation and serological findings are consistent with minocycline-induced autoimmune hepatitis.
  • Review of literature identified three types of minocycline-associated hepatotoxicity.

Implications:

  • This case underscores the potential for minocycline to induce autoimmune hepatitis.
  • Routine monitoring for autoimmune liver disease is recommended for patients on long-term minocycline therapy.
  • Further multicenter prospective trials are needed to evaluate the risk-benefit profile of extended minocycline use.