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Updated: Jul 3, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

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Published on: September 16, 2011

Eosinophilia and first-line coagulation testing.

Giuseppe Lippi¹, Martina Montagnana, Gian Luca Salvagno

¹Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona, Ospedale Policlinico G.B. Rossi, Verona, Italy. giuseppe.lippi@univr.it

Journal of Thrombosis and Thrombolysis

|July 12, 2008

Summary

This summary is machine-generated.

Eosinophilia, a prothrombotic condition, is linked to higher platelet counts and fibrinogen levels. This study suggests assessing these factors in patients with abnormal eosinophil counts to understand thrombosis risk.

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Area of Science:

Hematology
Clinical Pathology

Background:

Eosinophilia is recognized as a prothrombotic condition.
The association between eosinophil counts and standard coagulation tests is not well-established.

Purpose of the Study:

To investigate the relationship between blood eosinophil counts and routine coagulation parameters.
To explore potential mechanisms linking eosinophilia to thrombosis.

Main Methods:

Retrospective analysis of data from 6,944 outpatients aged over 15.
Inclusion of data on eosinophil counts, platelet count, fibrinogen, activated partial thromboplastin time (APTT), and prothrombin time (PT).

Main Results:

Patients with eosinophilia showed significantly higher median values for platelet count and fibrinogen.
A higher percentage of patients with eosinophilia had abnormal platelet counts and fibrinogen levels.
No significant association was found between eosinophilia and abnormal APTT or PT values.

Conclusions:

An epidemiological association exists between eosinophilia, elevated platelet counts, and fibrinogen levels.
Platelet count and fibrinogen may be valuable markers to assess in individuals with abnormal eosinophil counts.
Findings support the hypothesis that platelet and fibrinogen alterations contribute to the prothrombotic nature of eosinophilia.