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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
[Studies on solubility enhancement of curcumin by Polyvinylpyrrolidione K30]
Dong-hui Xu1, Sheng Wang, Xue-ting Mei
1Laboratory of TCM and Marine Drugs, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Objective:
To study solubility enhancement of curcumin by Polyvinylpyrrolidione K30 (PVP K30).
Methods:
Solid dispersion systems (SDS) of curcumin in PVP K30 were prepared at various weight ratios by co-evaporation of curcumin and PVP K30 ethanol solution. The differential scanning calorimetry (DSC) and powder X-ray diffractometer method were used to describe the status of curcumin in carriers, the UV spectrometry method for determination of curcumin in mediums was established.
Results:
The curcumin SDS was successfully prepared, the UV spectrometry method was accurate and reliable, and no interference occurred from carrier. The solubility rate in vitro of curcumin was significantly raised. Compared to curcumin, the solubility of curcumin in SDS increased at least 880 folds.
Conclusion:
PVP K30 improves the solubility of curcumin well.
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