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[Study on antitumor activity of extract from roots of Gossampinus malabaria]
Yi-Ping Qi1, Hui Zhu, Shun-Min Guo
1Fujian Provincial Institute of Medical Sciences, Fuzhou 350001, China.
Objective:
To study the antitumor activity of extract (Y2) from the roots of Gossampinus malabaria (L.) Merr.
Methods:
Based on the inhibitory effects of Y2 on FGC-85 in vitro, life-prolonging effects of Y2 on mice transplanted with ascites sarcoma-180 (S-180) and antitumor activity of Y2 on mice transplanted with U14 were investigated in vivo.
Results:
The growth of S-180 in mice was significantly inhibited by Y2. The inhibitory growth effect was dosage-dependent. Y2 could significantly prolong the survival time of mice transplanted with S-180. The inhibition rate of Y2 on the growth of U14 in mice was higher than 90% under high, medium and low dosage.
Conclusion:
Y2 has distinct antitumor activity.