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Updated: Jul 3, 2026
06:16
Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments
Published on: May 9, 2019
[The studies on the Ku Huang granula technology]
Summary
The optimal preparation technology for Ku Huang granula was identified using High-Performance Liquid Chromatography (HPLC) and orthogonal design. This research ensures the quality and efficacy of this traditional Chinese medicine formulation.
Area of Science:
- Pharmacology and Traditional Chinese Medicine
- Chemical Engineering and Process Optimization
Context:
- Ku Huang granula is a traditional Chinese medicine formulation requiring optimized production methods.
- Ensuring consistent quality and efficacy of herbal formulations is crucial for therapeutic outcomes.
Purpose:
- To determine the optimum technology for preparing Ku Huang granula.
- To screen the most effective preparatory technology using analytical methods and experimental design.
Summary:
- The study utilized High-Performance Liquid Chromatography (HPLC) for index determination and orthogonal design experiments to optimize the preparation of Ku Huang granula.
- The optimal conditions involved 100% dextrin for pelletization, spray drying at 170-175°C, and fluidizing pelletization with 75% ethyl alcohol at 85°C, 4 Hz for 3 hours.
Impact:
- Establishes a scientifically validated method for producing high-quality Ku Huang granula.
- Provides a foundation for reproducible manufacturing processes and potential scalability.
- Contributes to the standardization of traditional Chinese medicine production.
