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Updated: Jul 3, 2026
08:30
A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
Published on: September 16, 2022
[Skin and soft tissue infections: current therapeutic options]
Silvano Esposito1, Silvana Noviello, Sebastiano Leone
1Dipartimento di Malattie Infettive, Seconda Università degli studi di Napoli, Italy.
Le Infezioni in Medicina
|July 16, 2008
Summary
This review covers skin and soft tissue infections (SSTIs), focusing on Staphylococcus aureus and treatment guidelines. It highlights new antimicrobials like linezolid, tigecycline, and daptomycin for effective SSTI management.
Area of Science:
- Infectious Diseases
- Dermatology
- Microbiology
Background:
- Skin and soft tissue infections (SSTIs) are common pathologies with varied clinical presentations and etiologies.
- Severity of SSTIs correlates with the depth of tissue involvement.
- Staphylococcus aureus, including methicillin-resistant strains, is a frequent pathogen in SSTIs.
Purpose of the Study:
- To review classification criteria, etiology, and therapeutic options for SSTIs.
- To discuss internationally recommended guidelines for SSTI management based on clinical settings.
- To present recent data on the efficacy of novel antimicrobial agents for SSTIs.
Main Methods:
- Literature review of SSTI classification, etiology, and treatment.
- Analysis of current international guidelines for SSTI management.
- Evaluation of recent clinical data on new antimicrobials.
Main Results:
- SSTI management requires tailored approaches for mild versus severe infections.
- Guidelines emphasize different treatment strategies based on clinical settings.
- New antimicrobials like linezolid, tigecycline, and daptomycin show promise in treating SSTIs.
Conclusions:
- Effective SSTI management necessitates adherence to established guidelines and consideration of pathogen resistance.
- Novel antimicrobial agents offer new therapeutic avenues for complex SSTIs.
- Timely and aggressive treatment is crucial for severe SSTIs.
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