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Published on: May 31, 2021
An update on childhood urticaria and angioedema
1Loyola University Stritch School of Medicine, Chicago, Illinois, USA.
Insights
Urticaria, a common skin condition, presents in acute and chronic forms with diverse triggers. Understanding specific subtypes and their unique treatments, including novel therapies, is crucial for effective pediatric patient management.
Area of Science:
- Pediatric Dermatology
- Allergology and Immunology
- Clinical Medicine
Background:
- Urticaria, encompassing acute and chronic forms, is a prevalent condition in children.
- Identifying diverse triggers and subtypes is essential for effective management.
- The pathophysiology, diagnosis, and treatment of urticarial syndromes require ongoing updates.
Purpose of the Study:
- To review acute and chronic urticaria in pediatric populations.
- To discuss the differential diagnosis of urticarial syndromes.
- To provide updates on urticaria pathophysiology, diagnosis, and treatment.
Main Methods:
- Literature review of recent publications on pediatric urticaria.
- Analysis of diagnostic criteria and therapeutic approaches.
- Synthesis of information on urticaria subtypes and triggers.
Main Results:
- Urticaria subtypes show differential responses to therapies.
- Allergic and infectious triggers necessitate thorough patient evaluation.
- Distinguishing idiopathic urticaria from anaphylaxis, systemic conditions, and autoimmune urticaria is critical.
Conclusions:
- Urticaria is common, with increasing understanding of specific subtypes.
- Individualized patient assessment is vital to identify triggers and exclude other etiologies.
- Targeted therapies, including novel options like omalizumab, are advancing urticaria treatment.
Purpose Of Review:
The present review serves to address urticaria - both acute and chronic - as well as the differential diagnosis of urticarial syndromes in the pediatric population. We also wish to update the reader on progress in the pathophysiology, diagnosis and treatment of urticaria.
Recent Findings:
Acute and chronic urticaria represent syndromes caused by a variety of triggers. Recent literature continues to describe subtypes of urticaria that may be differentially responsive to particular therapies. Recent associations highlight the need to fully evaluate patients for allergic and infectious triggers of urticaria. It is important to distinguish idiopathic urticaria from related conditions such as anaphylaxis, systemic conditions and autoimmune urticaria. Although antihistamines remain a cornerstone of therapy, particular urticaria subtypes may also respond to novel therapies such as omalizumab. Chronic urticaria has a significant impact on a patient's quality of life.
Summary:
Urticaria is a common condition. Our understanding of distinct urticaria subtypes differentially responsive to targeted therapies continues to increase. Due to the myriad of triggers that may cause urticaria, careful individualized patient assessment is necessary to exclude potential etiologies prior to a diagnosis of idiopathic urticaria.
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