Related Experiment Video

Updated: Jul 3, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
05:23

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Elisabete Kawakami, Rodrigo Strehl Machado, Silvio Kazuo Ogata

    Arquivos De Gastroenterologia
    |July 16, 2008
    PubMed

    Insights

    Helicobacter pylori infection prevalence significantly decreased in children over a 10-year period, particularly in younger age groups and those with epigastric pain. This study tracked H. pylori trends in pediatric endoscopy patients.

    Area of Science:

    • Pediatric Gastroenterology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Global reports indicate a declining prevalence of Helicobacter pylori (H. pylori) infection.
    • Understanding H. pylori trends in pediatric populations is crucial for public health.
    • This study investigates H. pylori infection rates in children undergoing endoscopy.

    Purpose of the Study:

    • To evaluate the prevalence of Helicobacter pylori infection over a 10-year period in children.
    • To assess trends in H. pylori infection among pediatric patients undergoing upper digestive endoscopy.
    • To identify age-specific and symptom-related patterns in H. pylori prevalence.

    Main Methods:

    • Retrospective observational study of 1,165 pediatric endoscopies (age ≤ 18) over 10 years.
    • H. pylori infection diagnosed via rapid urease test on antral mucosal biopsy.
    • Chi-square for trend analysis used to compare prevalence over time.

    Main Results:

    • Overall H. pylori prevalence was 33.6% (392/1165).
    • Prevalence decreased from 60.47% in the first year to 30.43% in the last year.
    • Significant decreases observed in children under 6 and over 12, and notably in those with epigastric pain.

    Conclusions:

    • A significant decline in H. pylori infection prevalence was observed in the studied pediatric cohort.
    • The reduction in H. pylori infection was most pronounced in younger children and those presenting with epigastric pain.
    • Findings suggest a positive trend in controlling H. pylori in pediatric populations.
    Abstract

    More Related Videos

    Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis04:56

    Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis

    Published on: May 16, 2025

    Related Concept Videos

    Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

    Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

    Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
    Peptic Ulcer01:27

    Peptic Ulcer

    Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
    Gastritis II: Pathophysiology01:26

    Gastritis II: Pathophysiology

    The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
    Microbiota of the Stomach and Small Intestine01:27

    Microbiota of the Stomach and Small Intestine

    The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
    Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

    Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

    Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
    Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
    Development of Human Microbiota01:30

    Development of Human Microbiota

    The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...