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Published on: May 10, 2024
[Wheezing phenotypes from birth to adolescence: a cohort study in Pelotas, Brazil, 1993-2004]
Adriana Muiño1, Ana Maria Baptista Menezes, Felipe Fossati Reichert
1Hospital Maciel, Montevideo, Uruguai.
Insights
This study identified distinct wheezing patterns in adolescents, finding transient wheezing linked to socioeconomic and early-life factors. Understanding these patterns, like persistent and late-onset wheezing, aids in targeted preventive and therapeutic strategies for childhood respiratory health.
Area of Science:
- Pediatric Respiratory Medicine
- Epidemiology
- Longitudinal Cohort Studies
Context:
- Wheezing is a common respiratory symptom in childhood with varied developmental trajectories.
- Understanding the long-term patterns and associated risk factors is crucial for effective management.
- This study examines wheezing phenotypes from infancy through adolescence in a Brazilian cohort.
Purpose:
- To determine the prevalence of different wheezing patterns in adolescents.
- To investigate the associations between these wheezing patterns and various independent variables including socioeconomic, environmental, and familial factors.
- To inform preventive and therapeutic strategies based on identified risk factors.
Summary:
- A cohort study in Pelotas, Brazil, followed live births from 1993, evaluating wheezing at 6 months, 12 months, 4 years, and 10-12 years.
- Identified three main wheezing patterns: transient (43.9%), persistent (6.4%), and late-onset (3.3%).
- Transient wheezing associated with low income, shorter breastfeeding, and early respiratory infections. Persistent wheezing linked to male gender, maternal asthma, and family history. Late-onset wheezing associated with family asthma and rhinitis.
Impact:
- Provides crucial data on the epidemiology of childhood wheezing phenotypes.
- Highlights the importance of early-life factors and family history in predicting wheezing trajectories.
- Informs the development of targeted interventions for different wheezing patterns to improve long-term respiratory health outcomes.
Objective:
To study the prevalence of wheezing patterns and their associations with independent variables.
Methods:
Cohort study of live births in 1993 in Pelotas, Brazil. A systematic subsample (20%) of the original cohort was evaluated at 6 months, 12 months and 4 years. At 10-12 years, 87.5% of the original cohort was contacted. Wheezing was categorized: transient, wheezing at 4 years but not at 10-12; persistent, wheezing at all evaluations; late-onset, wheezing at 10-12 years. Independent variables were analyzed: gender; skin color; family income; smoking/asthma during pregnancy; breastfeeding; respiratory infection/diarrhea (during the 1st year); family members with asthma/allergy (at 4 years and at 10-12); physician-diagnosed rhinitis/eczema (at 10-12 years).
Results:
The subsample comprised 897 adolescents. Wheezing patterns were expressed as prevalence (95% CI): transient, 43.9% (40.7-47.2); persistent, 6.4% (4.8-8.0); and late-onset, 3.3% (2.2-4.5). The transient pattern was more common in children from low-income families, children breastfed for less time, children with a history of respiratory infections (during the 1st year) and children with asthma in the family (at 4 years). The persistent pattern was almost twice as common in males, in children whose mothers had asthma during pregnancy, in children with respiratory infections (during the 1st year) and in children with asthma in the family (at 4 and 10-12 years). The late-onset pattern was more prevalent among those with asthma in the family (at 10-12 years) and those diagnosed with rhinitis (at 10-12 years), being less prevalent among those reporting respiratory infections (during the 1st year) and those diagnosed with eczema (at 10-12 years).
Conclusions:
Knowledge of the associations of wheezing patterns allows us to adopt preventive and therapeutic measures.
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