[Wheezing phenotypes from birth to adolescence: a cohort study in Pelotas, Brazil, 1993-2004]

Adriana Muiño1, Ana Maria Baptista Menezes, Felipe Fossati Reichert

  • 1Hospital Maciel, Montevideo, Uruguai.

Insights

This study identified distinct wheezing patterns in adolescents, finding transient wheezing linked to socioeconomic and early-life factors. Understanding these patterns, like persistent and late-onset wheezing, aids in targeted preventive and therapeutic strategies for childhood respiratory health.

Area of Science:

  • Pediatric Respiratory Medicine
  • Epidemiology
  • Longitudinal Cohort Studies

Context:

  • Wheezing is a common respiratory symptom in childhood with varied developmental trajectories.
  • Understanding the long-term patterns and associated risk factors is crucial for effective management.
  • This study examines wheezing phenotypes from infancy through adolescence in a Brazilian cohort.

Purpose:

  • To determine the prevalence of different wheezing patterns in adolescents.
  • To investigate the associations between these wheezing patterns and various independent variables including socioeconomic, environmental, and familial factors.
  • To inform preventive and therapeutic strategies based on identified risk factors.

Summary:

  • A cohort study in Pelotas, Brazil, followed live births from 1993, evaluating wheezing at 6 months, 12 months, 4 years, and 10-12 years.
  • Identified three main wheezing patterns: transient (43.9%), persistent (6.4%), and late-onset (3.3%).
  • Transient wheezing associated with low income, shorter breastfeeding, and early respiratory infections. Persistent wheezing linked to male gender, maternal asthma, and family history. Late-onset wheezing associated with family asthma and rhinitis.

Impact:

  • Provides crucial data on the epidemiology of childhood wheezing phenotypes.
  • Highlights the importance of early-life factors and family history in predicting wheezing trajectories.
  • Informs the development of targeted interventions for different wheezing patterns to improve long-term respiratory health outcomes.
Abstract

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