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Effect of linezolid against postneurosurgical meningitis caused by methicillin-resistant Staphylococcus epidermidis:

Goro Nagashima1, Noriyoshi Okamoto, Muneo Okuda

  • 1Department of Neurosurgery, Fujigaoka Hospital, Showa University, 1-30 Fujigaoka, Yokohama, Kanagawa, 227-8501, Japan. goro-n@pol.dti2.ne.jp

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|July 16, 2008
PubMed

Insights

Linezolid effectively treated methicillin-resistant Staphylococcus epidermidis meningitis after neurosurgery when vancomycin failed. This highlights linezolid

Area of Science:

  • Neurosurgery
  • Infectious Diseases
  • Pharmacology

Background:

  • Recurrent tuberculum sellae meningioma surgery can lead to complications.
  • Post-surgical meningitis is a serious risk in neurosurgery patients.

Observation:

  • A patient developed meningitis caused by methicillin-resistant Staphylococcus epidermidis after multiple meningioma surgeries.
  • Initial treatment with vancomycin was ineffective due to poor cerebrospinal fluid (CSF) penetration.

Findings:

  • Linezolid administration resulted in the resolution of meningitis.
  • Linezolid demonstrated significant CSF penetration, achieving 58.9% of peak and 133% of trough serum concentrations.

Implications:

  • Linezolid is a crucial treatment option for neurosurgical site infections caused by MRSA.
  • Optimizing antibiotic selection based on CSF penetration is vital for successful meningitis treatment.

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