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Updated: Jul 3, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Cryoglobulinemia]
Tobias Ottl1, Marten Trendelenburg
1Abteilung Transplantationsimmunologie und Nephrologie, Medizinische Klinik, Universitätsspital Basel, Petersgraben 4, Basel. oettlt@uhbs.ch
Abstract:
Cryoglobulins are immunoglobulins that precipitate at temperatures below 37 degrees C. They mainly occur in association with hepatitis C but also in other persistent viral infections and autoimmune as well as hematologic diseases. As circulating immune-complexes, they can cause severe tissue damage in virtually all organs, in particular the skin, joints and kidneys. This article gives a review on the different types of cryoglobulinemia, their clinical presentation and current therapeutic strategies.
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