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Published on: October 6, 2016
Bone alterations during HIV infection
Elisa De Crignis1, Laura Cimatti, Marco Borderi
1Department of Clinical and Experimental Medicine, University of Bologna, Bologna, Italy. elisa.decrignis@gmail.com
Abstract:
Osteopenia and osteoporosis are common in HIV-1-infected individuals and represent a challenge in clinical and therapeutic management. Since the mechanisms underlying this degenerative process are largely unsettled and it has not yet been determined whether bone dysfunction is linked to HIV-1-mediated direct and/or indirect effects on osteoblasts/osteoclasts cross-talk regulation, this brief review analyzes an array of mechanisms that could account for the dramatic bone derangement (bone loss and osteopenia/osteoporosis) during the course of HIV-1 infection.
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