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Updated: Jul 3, 2026
08:54
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Butenafine and superficial mycoses: current status
1University College of Medical Sciences & GTB Hospital, Department of Dermatology & STD, Delhi - 110095, India. archanasingal@hotmail.com
Expert Opinion on Drug Metabolism & Toxicology
|July 16, 2008
Summary
Butenafine hydrochloride, a topical antifungal, effectively treats common fungal skin infections like tinea pedis and tinea corporis. It demonstrates excellent skin penetration and prolonged residual activity, offering therapeutic benefits even after application stops.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Butenafine hydrochloride is a benzylamine derivative with potent fungicidal activity.
- It is particularly effective against dermatophytes, aspergilli, and other fungi.
Purpose of the Study:
- To review the pharmacokinetics and mechanism of action of butenafine.
- To evaluate the clinical efficacy of butenafine for superficial fungal infections.
Main Methods:
- A comprehensive Medline search was conducted using the keyword 'butenafine'.
- English language articles were reviewed, prioritizing randomized controlled trials for efficacy assessment.
Main Results:
- Butenafine exhibits excellent epidermal penetration and prolonged retention, providing residual therapeutic activity.
- Topical butenafine 1% cream is effective for tinea pedis, tinea corporis, and tinea cruris in numerous trials.
Conclusions:
- Butenafine possesses anti-inflammatory properties.
- Its efficacy for pityriasis versicolor, seborrheic dermatitis, and candidal infections requires further investigation.
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