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Bacterial, fungal, parasitic, and viral myositis
1Infectious Diseases Division, Naval Medical Center, San Diego, California 92134-1005, USA. nancy.crum@med.navy.mil
Abstract:
Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection. For example, inciting events, including trauma, surgery, or the presence of foreign bodies or devitalized tissue, are often present in cases of bacterial myositis. Bacterial causes are categorized by clinical presentation, anatomic location, and causative organisms into the categories of pyomyositis, psoas abscess, Staphylococcus aureus myositis, group A streptococcal necrotizing myositis, group B streptococcal myositis, clostridial gas gangrene, and nonclostridial myositis. Fungal myositis is rare and usually occurs among immunocompromised hosts. Parasitic myositis is most commonly a result of trichinosis or cystericercosis, but other protozoa or helminths may be involved. A parasitic cause of myositis is suggested by the travel history and presence of eosinophilia. Viruses may cause diffuse muscle involvement with clinical manifestations, such as benign acute myositis (most commonly due to influenza virus), pleurodynia (coxsackievirus B), acute rhabdomyolysis, or an immune-mediated polymyositis. The diagnosis of myositis is suggested by the clinical picture and radiologic imaging, and the etiologic agent is confirmed by microbiologic or serologic testing. Therapy is based on the clinical presentation and the underlying pathogen.
Insights
Infectious myositis, though uncommon, can stem from various pathogens including bacteria, fungi, parasites, and viruses. Diagnosis relies on clinical signs, imaging, and lab tests, with treatment tailored to the specific cause.
Area of Science:
- Infectious Diseases
- Musculoskeletal System Disorders
- Microbiology
Background:
- Infectious myositis is a rare condition affecting muscle tissue, often occurring secondary to predisposing factors like trauma or foreign bodies.
- The musculature's inherent resistance makes infection uncommon, but a diverse range of pathogens can be implicated.
- Bacterial, fungal, parasitic, and viral agents are recognized causes of infectious myositis.
Purpose of the Study:
- To provide a comprehensive overview of infectious myositis.
- To categorize the different types of infectious myositis based on causative agents and clinical presentations.
- To highlight diagnostic approaches and therapeutic strategies for infectious myositis.
Main Methods:
- Review of literature on infectious myositis.
- Categorization of bacterial myositis based on clinical and etiological factors.
- Discussion of diagnostic modalities including clinical evaluation, imaging, and laboratory testing.
- Overview of treatment principles based on pathogen identification.
Main Results:
- Bacterial myositis presents in various forms, including pyomyositis, psoas abscess, and specific infections caused by Staphylococcus aureus, Streptococcus species, and Clostridium.
- Fungal myositis primarily affects immunocompromised individuals.
- Parasitic myositis is often linked to travel history and eosinophilia, with common causes being trichinosis and cysticercosis.
- Viral infections can lead to diffuse muscle involvement, manifesting as benign acute myositis, pleurodynia, or rhabdomyolysis.
Conclusions:
- Infectious myositis requires a multi-faceted diagnostic approach combining clinical suspicion, imaging, and microbiological confirmation.
- Effective management hinges on accurate identification of the causative agent and prompt, targeted therapy.
- Understanding the diverse etiologies is crucial for timely diagnosis and appropriate treatment of infectious myositis.
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