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[Treatment of chronic rhinitis in children]
Insights
Intestinal dysbiosis, or microbial imbalance, is linked to chronic rhinitis in children. Combined therapy targeting both nasal and gut microbes effectively treated inflammation and prevented relapse.
Area of Science:
- Microbiology
- Immunology
- Pediatrics
Context:
- Chronic rhinitis affects preschool children, impacting their quality of life.
- Intestinal dysbiosis is increasingly recognized as a factor in systemic inflammation.
- The relationship between gut microbiota and upper airway inflammation requires further investigation.
Purpose:
- To investigate the association between intestinal dysbacteriosis and chronic rhinitis in preschool children.
- To evaluate the efficacy of a combined therapeutic approach for microbial imbalances in the nasal cavity and intestine.
Summary:
- This study examined 42 preschool children with chronic rhinitis.
- A significant correlation was observed between nasal microbial changes and the severity of intestinal dysbiosis.
- Combined therapy demonstrated significant clinical and bacteriological improvements.
Impact:
- Combined treatment led to sustained remission in children with chronic rhinitis over a 4-month follow-up.
- Control group children receiving standard treatment experienced relapse within 2-3 weeks.
- This highlights the potential of targeting gut health for managing pediatric nasal inflammation.
Abstract:
This paper discusses involvement of intestinal dysbacteriosis in nasal inflammation. Altogether 42 children of preschool age with chronic rhinitis were examined. It was found that microbial changes in the nasal cavity were related to the degree of intestinal dysbacteriosis, which was detected in most patients. The drugs that were used in combined therapy to treat microbial changes in the nasal mucosa and intestine produced good clinical and bacteriological effects. The 4 month follow-up showed that the children on the combined therapeutic protocol remained in the remission stage throughout this time period, whereas 85 +/- 10% of the control children exhibited exacerbation of the inflammatory process in the nasal cavity within 2-3 weeks after onset of standard treatment.