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Small molecule receptors as imaging targets.

Aviv Hagooly¹, Raffaella Rossin, Michael J Welch

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus Box 8225, St. Louis, MO 63110, USA. hagoolya@mir.wustl.edu

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Summary

Molecular imaging targets aberrant receptors in diseased tissues using PET and SPECT tracers. This review covers small molecule tracers for receptor imaging in various disorders.

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Area of Science:

Molecular imaging and nuclear medicine.

Background:

Aberrant receptor expression in tumors and diseased tissues presents targets for molecular imaging.
Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) utilize radionuclides to label high-affinity ligands for these receptors.

Purpose of the Study:

To review aspects of receptor imaging using small molecule tracers with PET and SPECT.
To survey tracers for receptor imaging in tumors, brain, heart, and lung disorders.

Main Methods:

Review of literature on receptor imaging techniques.
Discussion of small molecule tracers for PET and SPECT.

Main Results:

Small molecule tracers enable molecular imaging of target receptors.
Functional information from receptor imaging aids understanding and applications in diagnostics and therapeutics.

Conclusions:

Receptor imaging with PET and SPECT offers valuable insights into various diseases.
Small molecule tracers are crucial for targeted molecular imaging in oncology and other disorders.