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Related Experiment Video

Updated: Jul 3, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Phage peptide display.

Jessica Newton1, Susan L Deutscher

  • 1Department of Biochemistry, University of Missouri, M743 Medical Sciences Bldg., Columbia, MO 65212, USA.

Handbook of Experimental Pharmacology
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

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Bacteriophage (phage) display technology is advancing cancer detection through novel peptide probes. Selected peptides, or phages themselves, show promise for in-vivo molecular imaging of tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Molecular imaging is crucial for in-vivo cancer diagnosis and monitoring.
  • Peptide-based probes targeting cancer hallmarks like apoptosis and angiogenesis are evolving.
  • Bacteriophage (phage) display technology is a key method for discovering tumor-targeting peptides.

Purpose of the Study:

  • To review the development and application of peptide-based molecular probes for cancer detection.
  • To highlight the role of phage display technology in identifying novel cancer-targeting peptides.
  • To discuss the potential of using selected phages as direct imaging agents for in-vivo tumor visualization.

Main Methods:

  • Utilizing phage display technology for ligand discovery to identify tumor-targeting peptides.

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Last Updated: Jul 3, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

A Protocol for Phage Display and Affinity Selection Using Recombinant Protein Baits
12:36

A Protocol for Phage Display and Affinity Selection Using Recombinant Protein Baits

Published on: February 16, 2014

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
06:30

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

  • Chemically synthesizing selected peptides and conjugating them with radiotracers or fluorescent probes.
  • Performing phage selections in live animals to optimize peptide stability and in-vivo targeting properties.
  • Exploring the direct use of selected phages as molecular imaging agents.

    • Main Results:

    • Numerous peptides binding to cancer cells and antigens have been identified using phage libraries.
    • In-vivo phage selections have yielded peptides with improved stability and targeting capabilities.
    • Vascular targeting peptides (e.g., RGD motif binding alpha(v)beta(3)integrin) show success due to integrin expression patterns.
    • The discovery of probes targeting tumor-specific antigens remains a challenge.

    Conclusions:

    • Phage display technology is a powerful tool for discovering peptides for cancer molecular imaging.
    • Vascular targeting peptides have demonstrated success in preclinical and clinical applications.
    • Further research is needed to develop probes targeting tumor-specific antigens.
    • Selected phages themselves represent a promising avenue for direct in-vivo cancer imaging.