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Leishmaniasis

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

American Trypanosomiasis

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

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Updated: Jul 3, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

[Cutaneous leishmaniasis].

U R Hengge¹, A Marini

¹Hautklinik, Heinrich-Heine-Universität Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf. Ulrich.Hengge@uni-duesseldorf.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|July 16, 2008

Summary

This summary is machine-generated.

Leishmaniasis is a group of diseases caused by Leishmania parasites, presenting diverse clinical forms and geographic distributions. Understanding these variations is key to diagnosis and treatment of this parasitic infection.

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Area of Science:

Parasitology
Infectious Diseases
Tropical Medicine

Context:

Leishmaniasis encompasses a range of diseases caused by parasites of the genus Leishmania.
Clinical presentation and severity vary significantly among affected individuals.
Classification often relies on clinical manifestations and geographical origin.

Purpose:

To provide an overview of the classification of leishmaniasis based on clinical features and geographic distribution.
To differentiate between Old World and New World leishmaniasis.

Summary:

Leishmaniasis presents as a spectrum of diseases with differing clinical appearances and health impacts.
Cutaneous leishmaniasis subtypes include localized, diffuse, recurrent, and post-kala-azar forms.
Old World leishmaniasis occurs in Africa, Asia, the Middle East, Mediterranean basin, and India, potentially causing cutaneous and visceral forms.
New World leishmaniasis, found in Central and South America, can manifest with cutaneous, mucocutaneous, and visceral disease.

Impact:

Facilitates a clearer understanding of the diverse clinical spectrum of leishmaniasis.
Aids in differentiating geographical variations and their associated disease manifestations.
Supports improved diagnostic and epidemiological approaches to leishmaniasis control.