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Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
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A CFSE-based Assay to Study the Migration of Murine Skin Dendritic Cells into Draining Lymph Nodes During Infection with Mycobacterium bovis Bacille Calmette-Gu&#233;rin
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[Cutaneous larva migrans].

N-P Hoff1, R Mota, A Groffik

  • 1Hautklinik der Heinrich-Heine-Universität, Moorenstrasse 5, 40225 Düsseldorf.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Cutaneous larva migrans, a common tropical disease from hookworm infection, causes itchy, winding rashes on exposed skin. This self-limiting condition typically resolves within weeks with local treatment.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Parasitology

Context:

  • Mass tourism and affordable exotic travel increase exposure to tropical diseases.
  • Cutaneous larva migrans is a frequent dermatological souvenir from tropical regions.
  • The condition results from hookworm parasites, specifically Ancylostoma braziliense or A. caninum.

Purpose:

  • To describe the etiology, clinical presentation, and management of cutaneous larva migrans.
  • To highlight the increasing relevance of tropical diseases in dermatology due to global travel.

Summary:

  • Cutaneous larva migrans is characterized by serpiginous, erythematous skin lesions with intense pruritus.
  • Larval migration occurs within the epidermis after parasite penetration, often on feet, calves, or buttocks.
  • The infection is typically self-limiting, resolving in weeks, and managed with local therapies like cryotherapy.

Impact:

  • Provides essential information for dermatologists managing imported skin diseases.
  • Emphasizes the need for awareness of tropical infections in travelers.
  • Highlights the generally excellent prognosis despite potential complications like superinfection.