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Updated: Jul 3, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Long-term management of generalized pustular psoriasis with infliximab: case series
Shannon B Routhouska1, Pranav B Sheth, Neil J Korman
1Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, USA.
Background:
Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports.
Objective:
The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab.
Methods:
Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab.
Results:
Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate.
Conclusion:
Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.
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