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Related Experiment Videos

White sponge nevus.

Chicky Dadlani1, Stephanie Mengden, A Ross Kerr

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

White sponge nevus is a rare, inherited disorder causing asymptomatic white plaques on the oral mucosa. This case highlights a sporadic presentation, emphasizing the need for careful diagnosis in individuals without a family history.

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Area of Science:

  • Oral pathology
  • Dermatology
  • Genetics

Background:

  • White sponge nevus is a rare, inherited disorder affecting the oral mucosa.
  • It typically presents as asymptomatic, white, folded plaques.
  • Genetic mutations in KRT5 and KRT13 are commonly associated with this condition.

Observation:

  • A 33-year-old man presented with a 13-year history of asymptomatic, white, folded, soft, poorly-demarcated, diffuse plaques on his buccal mucosae and lateral tongue surfaces.
  • The lesions were bilateral and had persisted for over a decade.
  • No family history of similar lesions was reported.

Findings:

  • Physical examination and histopathologic findings were consistent with white sponge nevus.
  • The diagnosis was confirmed despite the absence of a familial background.

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  • This suggests a possible sporadic mutation or incomplete penetrance in affected families.

    • Implications:

    • This case underscores that white sponge nevus can occur sporadically, not exclusively as an inherited condition.
    • Accurate diagnosis is crucial for appropriate patient management and genetic counseling.
    • Further research into the genetic underpinnings of sporadic cases may reveal novel insights into keratin disorders.