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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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iSPOT: a web tool for the analysis and recognition of protein domain specificity

B Brannetti1, A Zanzoni, L Montecchi-Palazzi

  • 1Department of Biology, University of Rome Tor Vergata, Rome, Italy.

Comparative and Functional Genomics
|July 17, 2008
PubMed

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Conservation of Protein Domains Over Different Proteins

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Conservation of Protein Domains02:26

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Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
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