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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Synthesis, Hemoglobin Encapsulation and Biorthogonal PEGylation in Hierarchically Porous UiO-66 Nanoparticles for Oxygen Delivery Applications
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Poly(organo phosphazene) nanoparticles surface modified with poly(ethylene oxide).

J Vandorpe1, E Schacht, S Stolnik

  • 1Department of Organic Chemistry, Biomaterial and Polymer Research Group, University of Ghent, Ghent, Belgium.

Biotechnology and Bioengineering
|October 5, 1996
PubMed
Summary

Biodegradable poly(organo phosphazene) nanoparticles were created and surface-modified using poly(ethylene oxide) derivatives. Surface modification improved colloidal stability but was less effective than Poloxamine 908.

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10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

  • Polymer chemistry
  • Nanotechnology
  • Materials science

Background:

  • Biodegradable polymers are crucial for advanced drug delivery systems.
  • Poly(organo phosphazenes) offer tunable properties for nanoparticle fabrication.
  • Surface modification is key to enhancing nanoparticle performance and stability.

Purpose of the Study:

  • To synthesize and characterize biodegradable poly(organo phosphazene) nanoparticles.
  • To investigate surface modification of these nanoparticles with a novel poly(ethylene oxide) derivative.
  • To assess the impact of surface modification on nanoparticle properties and colloidal stability.

Main Methods:

  • Nanoparticle preparation via precipitation solvent evaporation.
  • Particle size reduction achieved by pH adjustment.
  • Surface modification using poly[(glycine ethyl ester)phosphazene) with poly(ethylene oxide) side groups.
  • In vitro characterization including surface potential and colloidal stability assessments.

Main Results:

  • Nanoparticles <200 nm were formed, with size influenced by hydrophobic and electrostatic interactions.
  • Surface modification created a ~35 nm coating layer.
  • Coated nanoparticles showed reduced surface potential and improved colloidal stability.
  • Steric stabilization was less effective compared to Poloxamine 908.

Conclusions:

  • Biodegradable poly(organo phosphazene) derivatives are suitable for nanoparticle preparation.
  • Surface modification with poly(ethylene oxide) enhances nanoparticle stability.
  • The arrangement of poly(ethylene oxide) chains influences steric stabilization effectiveness.