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Updated: Jul 3, 2026
05:22
A Multiplex Serological Assay for the Detection of Antibody Responses to Arboviruses
Published on: November 4, 2025
[Ventricular dysfunction during acute fever in Dakar, Senegal. Clinical data and serological studies]
A Cénac1, A Traore-Kissima, A Ba Serigne
1EA-948, Unité de Formation et de Recherche en Médecine de Brest, Université de Bretagne Occidentale. arnaud.cenac@chu-brest.fr
Medecine Tropicale : Revue Du Corps De Sante Colonial
|July 17, 2008
Summary
Severe acute myocarditis can cause ventricular dysfunction during fever. Antimicrobial therapy with macrolides may be effective, especially when caused by Chlamydia or Mycoplasma pneumoniae infections.
Area of Science:
- Cardiology
- Infectious Diseases
- Microbiology
Context:
- Ventricular dysfunction during acute fever is a recognized clinical presentation.
- Severe acute myocarditis is a potential cause of this dysfunction.
- Identifying infectious agents is crucial for guiding treatment.
Purpose:
- To investigate the link between severe acute myocarditis, ventricular dysfunction, and specific infectious agents.
- To evaluate the potential of antimicrobial therapy in managing these cases.
Summary:
- The study observed clinical and ultrasound evidence of ventricular dysfunction during acute fever, attributed to severe acute myocarditis.
- Chlamydia (CT and especially CP) and Mycoplasma pneumoniae were identified in 4/8 patients, both sensitive to macrolide antibiotics.
- Coinfections with multiple agents (CP-enterovirus-adenovirus) were present in 5/8 patients, highlighting complex etiology.
Impact:
- Findings support therapeutic management strategies for severe acute myocarditis.
- Highlights the role of specific bacterial infections like Chlamydia and Mycoplasma pneumoniae.
- Suggests macrolide antibiotics as a potential treatment option for identified pathogens.
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