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[A comparative study on effect of bacterial load in diabetic foot ulcers dealing with iodophor and rivanol
Wenzhong Chen1, Kai Xu, Hui Zhang
1Department of Plastic Surgery, No.2 Hospital, Shanxi Medical University, Taiyuan Shanxi, 030001, P.R. China.
Objective:
To investigate the change of bacterial load applied with iodophors and rivanol of diabetic foot ulcers (DFUs), furthermore to evaluate the effect of both in removing superficial microbes of DFUs.
Methods:
From March 2006 to March 2007, 30 patients were randomly divided into control group (group A, n = 10), iodophor group (group B, n = 10) and rivanol group (group C, n = 10). There were 18 males and 12 females with an average age of 59.8 years (range 46-78 years). The wound size ranged from 3 cm x 2 cm to 15 cm x 10 cm. The disease course was 6 weeks to 6 months (mean 2.1 months). Each wound was debrided and irrigated before process, then drug was compressed on the wound for 5 minutes, and irrigated again. The samples gained for three times, before, immediately and 24 hours after the process. Each sample was diluted before cultivation, the bacteria of wound were counted and compared among 3 groups.
Results:
The cultures of specimens showed that the load decreased in every group, each cultured colony of specimen grew well, and there were no significant differences between 3 groups immediately after procedure (P > 0.05). There were significant differences between group B and groups A, C (P < 0.05), but there were no significant difference between group A and group C 24 hours after treatment (P > 0.05).
Conclusion:
Both iodophors and rivanol could remove the bacteria on the surface of wound. Topical germicide could reduced bacterial load in the wound of diabetic foot, the role of sterilizing and bacteriostasis of iodophors were better than that of rivanol.
Insights
Both iodophors and rivanol reduce bacterial load in diabetic foot ulcers (DFUs). Iodophors demonstrated superior sterilizing and bacteriostatic effects compared to rivanol 24 hours post-treatment.
Area of Science:
- Microbiology
- Dermatology
- Infectious Diseases
Background:
- Diabetic foot ulcers (DFUs) are prone to bacterial infections, complicating wound healing.
- Controlling bacterial load is crucial for managing DFUs and preventing further complications.
Purpose of the Study:
- To compare the efficacy of iodophors and rivanol in reducing bacterial load on DFU surfaces.
- To evaluate the antimicrobial effects of these agents over time.
Main Methods:
- A randomized controlled trial involving 30 DFU patients, divided into control, iodophor, and rivanol groups.
- Bacterial samples were collected pre-treatment, immediately post-treatment, and 24 hours post-treatment.
- Bacterial load was quantified through colony counts after cultivation.
Main Results:
- Bacterial load decreased in all groups, with no significant immediate post-treatment differences.
- Iodophors showed significantly greater bacterial reduction compared to control and rivanol groups at 24 hours.
- No significant difference in bacterial reduction was observed between control and rivanol groups at 24 hours.
Conclusions:
- Both iodophors and rivanol effectively reduce superficial bacteria in DFUs.
- Iodophors exhibit superior sterilizing and bacteriostatic properties over rivanol for DFU treatment.
- Topical antiseptics can significantly reduce bacterial burden in diabetic foot wounds.
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