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Updated: Jul 3, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Mucosal immunity with emphasis on urinary tract immunity and diabetes]
J Krejsek1, M Kudlová, M Kolácková
1Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN Hradec Králové. krejsek@fnhk.cz
Abstract:
Protective immune response in urinary tract is frequently impaired in patients with diabetes. Immunity in this mucosal compartment displays unique characteristics; e.g. absence of physiological microflora and lack of mucus. Pathogens are identified by the PRR receptors expressed on both epithelial and immune cells. Inflammatory response characterised by the acumulation ofgranulocytes is followed. Both protective and harm characteristics of inflammatory response are inseparable linked and delineated by gene polymorphisms in PRR receptors.
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