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Related Concept Videos

Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...

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Related Experiment Video

Updated: Jul 3, 2026

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
13:22

Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface

Published on: November 2, 2011

Quantifying nanoparticle adhesion mediated by specific molecular interactions.

Jered B Haun1, Daniel A Hammer

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|July 18, 2008
PubMed
Summary
This summary is machine-generated.

Nanoparticle adhesion to diseased cells depends on receptor and ligand density, not flow rate. Detachment follows a time-dependent power law, guiding the design of targeted nanoparticle therapeutics.

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Last Updated: Jul 3, 2026

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Biophysics

Background:

  • Receptor-mediated targeting of nanoparticles is promising for vascular diseases.
  • Predicting nanoparticle adhesion under flow is challenging due to complex interactions.

Purpose of the Study:

  • To investigate the impact of adhesion molecule density and flow rate on nanoparticle adhesion.
  • To establish criteria for optimizing nanoparticle binding efficiency and selectivity.

Main Methods:

  • Utilized a flow chamber system with nanoparticles functionalized with ICAM-1 specific antibodies.
  • Varied antibody density, ligand density (ICAM-1), and flow rate.
  • Employed a transport-reaction model to determine kinetic rate constants for adhesion and detachment.

Main Results:

  • Nanoparticle attachment and detachment correlated with receptor and ligand valency, minimally affected by shear rate.
  • Discovered a time-dependent power law mechanism for particle detachment, decreasing with contact time.
  • Demonstrated how to engineer adhesion selectivity for targeted molecular applications.

Conclusions:

  • Adhesion and dissociation principles for nanoparticles are established.
  • Results provide a framework for rational design of targeted nanoparticle therapeutics with optimized adhesive properties.