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Annulate lamellae in an undifferentiated mouse marrow cell
1Department of Anatomy, University of Miami School of Medicine, Miami, Florida, U.S.A.
Tissue & Cell
|January 1, 1970
Summary
Annulate lamellae were found in undifferentiated mouse marrow cells after urethane treatment. These structures were absent in control groups, suggesting they may identify primitive stem cells.
Area of Science:
- Cell Biology
- Hematology
- Developmental Biology
Background:
- Annulate lamellae are a poorly understood cytoplasmic organelle.
- Their presence and function in mammalian cells, particularly primitive marrow cells, require further investigation.
Purpose of the Study:
- To investigate the presence and potential significance of annulate lamellae in mouse bone marrow cells.
- To determine if annulate lamellae can serve as a marker for primitive hematopoietic stem cells.
Main Methods:
- Mice were injected with urethane or saline as a control.
- Bone marrow cells were examined for the presence of annulate lamellae using microscopy.
Main Results:
- Annulate lamellae were observed in undifferentiated cells of urethane-treated mice.
- These structures were not found in any recognizable hematopoietic cells of control mice (saline- or urethane-injected).
Conclusions:
- Annulate lamellae may be confined to the most primitive marrow cells.
- This cytoplasmic organelle could potentially serve as an identifying feature of stem cells.
