Related Experiment Video
Updated: Jul 3, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Memory health clinics-a first step to prevention
Bruno Vellas1, Sophie Gillette-Guyonnet, Sandrine Andrieu
1Department of Internal Medicine and Clinical Gerontology, Gerontopole, Toulouse Université Hospital, CHU La Grave-Casselardit, Toulouse, France; Inserm U 558, Toulouse, France. vellas.b@chu-toulouse.fr
Multi-domain strategies targeting Alzheimer's disease (AD) prevention may be more impactful than single interventions. This approach leverages multiple protective factors for greater success in international trials.
Area of Science:
- Neurology
- Gerontology
- Preventive Medicine
Background:
- Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder.
- Current treatment strategies have limitations in halting disease progression.
- The need for effective primary prevention is critical.
Purpose of the Study:
- To present the rationale for adopting multi-domain preventive approaches for Alzheimer's disease.
- To advocate for large-scale international trials focusing on comprehensive prevention strategies.
- To highlight the potential impact of multi-domain interventions compared to single-target therapies.
Main Methods:
- Discussion and conceptualization of international, multi-domain preventive trials.
- Review of the multifactorial nature of Alzheimer's disease.
- Consideration of combining various protective factors in trial design.
Main Results:
- Multi-domain strategies are proposed as a more effective approach to Alzheimer's disease prevention.
- International collaboration in North America and the European Union is envisioned for large-scale trials.
- The potential impact of multi-domain approaches is considered significantly greater than single interventions.
Conclusions:
- Multi-domain preventive strategies offer a promising avenue for Alzheimer's disease research.
- International collaboration is key to implementing large-scale preventive trials.
- A comprehensive approach utilizing multiple protective factors is recommended for future Alzheimer's disease prevention efforts.
More Related Videos
06:58Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
Published on: January 24, 2020
07:01Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
Related Concept Videos
Preventive Healthcare Services
Levels of Health Promotion and Illness Prevention
In primary prevention, actions taken before disease onset prevent the disease from...
Dementia
The progression of dementia is generally gradual.
Cognitive Development During Adulthood
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Understanding Memory