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Related Experiment Video

Updated: Jul 3, 2026

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
13:42

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep

Published on: January 19, 2014

[SAPHO syndrome--clinical features].

Hanna Przepiera-Bedzak1, Iwona Brzosko, Jacek Fliciński

  • 1Klinika Reumatologii Pomorskiej Akademii Medycznej w Szczecinie.

Polskie Archiwum Medycyny Wewnetrznej
|July 19, 2008
PubMed
Summary
This summary is machine-generated.

SAPHO syndrome, a condition linking skin pustules and chest pain, was studied in 17 patients. Early diagnosis relies on recognizing these key clinical features for effective management.

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Last Updated: Jul 3, 2026

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
13:42

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep

Published on: January 19, 2014

Area of Science:

  • Rheumatology
  • Dermatology
  • Clinical Medicine

Background:

  • SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) syndrome is a rare autoinflammatory disorder.
  • Clinical presentation can be variable, often leading to diagnostic challenges.

Purpose of the Study:

  • To present the clinical features of SAPHO syndrome.
  • To highlight diagnostic indicators and treatment approaches.

Main Methods:

  • Retrospective analysis of 17 patients (15 female, 2 male) with confirmed SAPHO syndrome.
  • Clinical examination, laboratory tests (ESR, CRP, Waaler-Rose, ANA), skin biopsy cultures, X-rays, and bone scintigraphy were performed.

Main Results:

  • Patients aged 22-59 years; mean symptom duration 4.4 years.
  • 16 patients had pustulosis, 1 had acne; all experienced anterior chest wall pain.
  • Peripheral joint involvement (wrist, shoulder, knee) noted in several patients; elevated ESR/CRP in 12.
  • Radiographic and scintigraphic findings supported SAPHO diagnosis in most patients.

Conclusions:

  • The association of characteristic skin lesions with anterior chest wall pain is crucial for SAPHO syndrome diagnosis.
  • SAPHO syndrome may be more prevalent in Poland than previously recognized.