Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distribution and morphological features of astrocytes and Purkinje cells in the human cerebellum.

Frontiers in neuroanatomy·2025
Same author

Single-cell omics and heterogeneity of neuroglial cells.

Handbook of clinical neurology·2025
Same author

An Astrocyte Transplantation Method to Investigate Astrocyte Development and Diversity in the Central Nervous System (CNS).

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.

Cell reports·2024
Same author

Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys.

The Journal of comparative neurology·2024
Same author

Astrocyte morphology.

Trends in cell biology·2024
Same journal

Release of neurotransmitters from glia.

Neuron glia biology·2012
Same journal

Analysis of glutathione S-transferase genes polymorphisms and the risk of schizophrenia in a sample of Iranian population.

Neuron glia biology·2012
Same journal

TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation.

Neuron glia biology·2012
Same journal

ATP derived from astrocytes modulates memory in the chick.

Neuron glia biology·2012
Same journal

Exposure to environmental enrichment prior to a cerebral cortex stab wound attenuates the postlesional astroglia response in rats.

Neuron glia biology·2012
Same journal

Direct and glia-mediated effects of GABA on development of central olfactory neurons.

Neuron glia biology·2012
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

A Simplified Method for Ultra-Low Density, Long-Term Primary Hippocampal Neuron Culture
11:19

A Simplified Method for Ultra-Low Density, Long-Term Primary Hippocampal Neuron Culture

Published on: March 5, 2016

Reshaping neuron-glial communication at hippocampal synapses.

Michael Haber1, Keith K Murai

  • 1Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Canada.

Neuron Glia Biology
|July 19, 2008
PubMed
Summary
This summary is machine-generated.

Astrocyte-synapse interactions in the hippocampus are complex and involve structural remodeling. Understanding these neuron-glial dynamics is key to synaptic plasticity, function, and neurological diseases.

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Low-Density Primary Hippocampal Neuron Culture
17:46

Low-Density Primary Hippocampal Neuron Culture

Published on: April 18, 2017

Related Experiment Videos

Last Updated: Jul 3, 2026

A Simplified Method for Ultra-Low Density, Long-Term Primary Hippocampal Neuron Culture
11:19

A Simplified Method for Ultra-Low Density, Long-Term Primary Hippocampal Neuron Culture

Published on: March 5, 2016

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Low-Density Primary Hippocampal Neuron Culture
17:46

Low-Density Primary Hippocampal Neuron Culture

Published on: April 18, 2017

Area of Science:

  • Neuroscience
  • Cell Biology
  • Neurobiology

Background:

  • Neuron-glial interactions are fundamental to nervous system functions like synaptic transmission.
  • The relationship between astrocytes and neurons at central nervous system (CNS) synapses is intricate.
  • Astrocytic membranes near synaptic elements regulate synaptic transmission and plasticity.

Purpose of the Study:

  • To review the structural complexities of astrocyte-synapse interactions in the hippocampus.
  • To explore the implications of these interactions for synaptic physiology, behavior, and disease.

Main Methods:

  • This review synthesizes findings from recent investigations.
  • Focuses on structural remodeling of neuronal and glial components in the hippocampus.
  • Examines the dynamic regulation of the synapse and its microenvironment by astrocytes.

Main Results:

  • Astrocytes and neurons exhibit rapid, continuous structural remodeling in the hippocampus.
  • Physical modifications in astrocyte-neuron structures significantly impact neurotransmission.
  • Astrocytic morphology remodeling is crucial for dynamic synapse regulation.

Conclusions:

  • Astrocyte-synapse structural complexity is vital for hippocampal synaptic physiology.
  • Understanding these interactions offers insights into behavior and neurological disorders.
  • Dynamic astrocyte morphology plays a critical role in synaptic function and microenvironment regulation.