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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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Published on: September 30, 2007

A microfluidic cell array with individually addressable culture chambers.

Hsiang-Yu Wang¹, Ning Bao, Chang Lu

¹School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Biosensors & Bioelectronics

|July 19, 2008

Summary

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This study introduces a microfluidic cell array for high-throughput screening. The system enables precise cell culture and drug treatment in individually controlled chambers, advancing cell-based assay development.

Area of Science:

Biotechnology
Cell Biology
Microfluidics

Background:

Microfluidic arrays offer potential for high-throughput cell-based screening.
Precise control over individual cell cultures is crucial for detailed analysis.

Purpose of the Study:

To present a novel microfluidic cell array with individually addressable chambers.
To demonstrate its utility in cell culture and targeted reagent delivery for drug screening.

Main Methods:

Development of a microfluidic array featuring pneumatic valves for chamber control.
Operation in two modes: differential cell seeding and targeted reagent application.
Demonstration using Chinese hamster ovary (CHO) cells and fluorescent markers.

Main Results:

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Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip

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Last Updated: Apr 27, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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A Microfluidic Platform for High-throughput Single-cell Isolation and Culture

A Microfluidic Platform for High-throughput Single-cell Isolation and Culture

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Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip

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Successful directed delivery and culture of enhanced green fluorescent protein (EGFP)-expressing and nonfluorescent CHO cells.
Effective treatment of specific cell populations with Calcein AM and CellTrace calcein red-orange AM.
Validation of the microfluidic system's capability for controlled cellular assays.

Conclusions:

The developed microfluidic cell array facilitates precise control over cell culture and treatment.
This technology supports automated, high-throughput screening of biomolecules and drugs.
It holds promise for advancing cellular phenotype and response analysis in drug discovery.