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Published on: August 13, 2019
Sleep duration and risk of ischemic stroke in postmenopausal women
Jiu-Chiuan Chen1, Robert L Brunner, Hong Ren
1Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599-7435, USA. jcchen@unc.edu
Background And Purpose:
Many studies have shown a U-shape association between sleep duration and mortality, but epidemiological evidence linking cardiovascular diseases with habitual sleep patterns is limited and mixed.
Methods:
We conducted a prospective study on 93 175 older women (aged 50 to 79 years) in the Women's Health Initiative Observational study cohort to examine the risk of ischemic stroke in relation to self-reported sleep duration. Cox models were used to investigate the putative associations, adjusting for multiple sociodemographic and lifestyle factors, depression, snoring, sleepiness symptoms, and other cardiovascular disease-related clinical characteristics.
Results:
At baseline, 8.3% of subjects had reported their sleep duration as
Conclusions:
Habitual sleep patterns are important neurobehavioral determinants of risk for ischemic stroke in postmenopausal women. The underlying neurobiology and mechanistic mediators for the putative adverse effect of long sleep (>or=9 hours/night) need further elucidation.
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