[Juvenile angiofibroma in adults]
Marek Łukomski1, Marian Danilewicz, Anna Pajor
1Klinika Laryngologii Onkologicznej UM w Łodzi, Uniwersyteckiego Szpitala Klinicznego nr 1 im. N. Barlickiego.
Otolaryngologia Polska = the Polish Otolaryngology
|July 22, 2008
Summary
This study presents rare cases of juvenile nasopharyngeal angiofibroma in adult males and a female, challenging typical age and sex characteristics. Findings suggest a need to reconsider the pathogenesis and clinical presentation of this benign tumor.
Area of Science:
- Otolaryngology
- Head and Neck Surgery
- Pathology
Background:
- Juvenile nasopharyngeal angiofibroma (JNA) is typically characterized by its occurrence in adolescent males.
- JNAs are neoplasms originating in the nasopharynx.
Observation:
- This study details three atypical cases of JNA: two adult males (34 and 49 years) and one female (68 years).
- All patients presented with tumors in the typical nasopharyngeal location, with extension to paranasal sinuses in two cases.
- Histological findings were consistent with JNA, despite the atypical demographics.
Findings:
- Surgical treatment was performed, with one recurrence after two years successfully managed by reoperation.
- Two patients showed no recurrence during follow-up.
- Histological examination confirmed JNA in all atypical cases.
Implications:
- The occurrence of JNA in adult females and older males broadens the clinical spectrum of this neoplasm.
- These findings prompt a re-evaluation of the pathogenesis and clinical understanding of juvenile nasopharyngeal angiofibroma.
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