Expression of the Selected Proteins of JAK/STAT Signaling Pathway in Diseases with Oral Mucosa Involvement

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Kamila Ociepa1, Marian Danilewicz2, Małgorzata Wągrowska-Danilewicz3

  • 1Department of Dermatology and Venereology, Medical University of Lodz, 90-674 Lodz, Poland.

International Journal of Molecular Sciences
|January 8, 2023
PubMed

Insights

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is implicated in autoimmune bullous diseases. This study found elevated JAK/STAT protein expression in lesions, suggesting it as a therapeutic target.

Area of Science:

  • Immunology
  • Molecular Biology
  • Dermatology

Background:

  • The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway regulates cell functions and is implicated in inflammatory and autoimmune diseases.
  • Limited research exists on JAK/STAT pathway involvement in autoimmune bullous diseases.

Purpose of the Study:

  • To investigate the expression of JAK3, STAT2, STAT4, and STAT6 proteins in oral mucosal lesions of patients with pemphigus vulgaris (PV), bullous pemphigoid (BP), oral lichen planus (LP), and chronic ulcerative stomatitis (CUS).
  • To compare protein expression in disease lesions against a healthy control group.

Main Methods:

  • Immunohistochemistry and immunoblotting techniques were employed.
  • Expression levels of JAK3, STAT2, STAT4, and STAT6 were quantified in epithelial lesions.

Main Results:

  • Significantly higher expression of selected JAK/STAT pathway proteins was observed in the lesions of PV, BP, LP, and CUS patients compared to controls.
  • Elevated STAT2 expression was not found in bullous pemphigoid (BP) and pemphigus vulgaris (PV) lesions.
  • Elevated STAT4 expression was not observed in chronic ulcerative stomatitis (CUS) and oral lichen planus (LP) lesions.
  • Distinct expression patterns of JAK/STAT proteins were noted across the studied autoimmune bullous diseases.

Conclusions:

  • The JAK/STAT pathway plays a role in the pathogenesis of autoimmune bullous diseases.
  • The observed differences in protein expression suggest specific roles for JAK/STAT proteins in different conditions.
  • These findings highlight potential new therapeutic targets for treating autoimmune bullous diseases.
Keywords:
CUSJAK/STATlichen planuspemphigoidpemphigus

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